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Worksheet for Using an Article About
Therapy or Prevention


Worksheet: PDF (printable worksheet) WORD (fill in on-line)

Citation:

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Are the Results of the Study Valid?

1.Was the assignment of patients to treatment randomized?

[ ] Yes [ ] No [ ] Can't Tell


2. Were all patients who entered the trial properly accounted for and attributed at its conclusion?

arrowWas follow-up complete?
arrowWere patients analyzed in the groups to which they were randomized (intention to treat analysis)?

[ ] Yes [ ] No [ ] Can't Tell


3. Were patients, their clinicians, and study personnel 'blind' to treatment?

[ ] Yes [ ] No [ ] Can't Tell


4. Were the groups similar at the start of the trial?

arrowBaseline prognostic factors (demographics, co-morditity, disease severity, other known confounders) balanced?
arrow If different, were these adjusted for?

[ ] Yes [ ] No [ ] Can't Tell


5. Aside from the experimental intervention, were the groups treated equally?

arrowCo-intervention?
arrowContamination?
arrowCompliance?

[ ] Yes [ ] No [ ] Can't Tell


6. Overall, are the results of the study valid?

[ ] Yes [ ] No [ ] Can't Tell


What are the Results

1. How large was the treatment effect?

arrowAbsolute risk reduction?
arrowRelative risk reduction?


2. How precise was the estimate of the treatment effect?

arrowConfidence intervals?


Will the Results Help Me in Caring for My Patients?

1. Can the results be applied to my patient care?

arrowPatients similar for demographics, severity, co-morbidity and other prognostic factors?
arrowCompelling reason why the results should not be applied?

[ ] Yes [ ] No [ ] Can't Tell


2. Were all clinically important outcomes considered?

arrowAre substitute endpoints valid?

[ ] Yes [ ] No [ ] Can't Tell


3. Are the likely treatment benefits worth the potential harms and costs?

arrowNNT for different outcomes?

[ ] Yes [ ] No [ ] Can't Tell


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